Medications for bedwetting

What types of medications are used to treat bedwetting?

Among the drugs, imipramine (tofranil) is often used to treat both children and adults with enuresis. The drug goes by several names including Imiprex, tofranil and Sermonil. Imipramine is a good drug for the treatment of depression, various pain syndromes, insomnia and neuropathy. Tofranil has been used to treat enuresis for more than 3 decades. 

The lowest dosage of Tofranil is usually administered and the response to bed wetting is observed. Most people begin to see a response in a few days. The dose is usually increased if no response is seen after 2 weeks. The initial success rates of tofranil are low. Only 10%-20% of children and about 25% of adults respond to this therapy. However, for some unknown reason with continued long-term treatment, its effectiveness disappears.